"After experimenting on himself and becoming invisible, scientist Jack Griffin, now aggressive due to the drug's effects, seeks a way to reverse the experiment at any cost."
Claude Rains
as Dr. Jack Griffin
Gloria Stuart
as Flora Cranley
William Harrigan
as Dr. Arthur Kemp
Henry Travers
as Dr. Cranley
Una O'Connor
as Jenny Hall
Forrester Harvey
as Herbert Hall
Holmes Herbert
as Chief of Police
E. E. Clive
as Constable Jaffers
Dudley Digges
as Chief Detective
Harry Stubbs
as Inspector Bird
Donald Stuart
as Inspector Lane
Merle Tottenham
as Millie
Robert Adair
as Detective Thompson (uncredited)
Edgar Barrier
as Radio Announcer (uncredited)
Ted Billings
as Villager Playing Darts (uncredited)
Walter Brennan
as Bicycle Owner (uncredited)
Robert Brower
as Farmer (uncredited)
Mae Bruce
as Mary Purdy (uncredited)
Rita Carlyle
as Townswoman at Pub (uncredited)
John Carradine
as Informer Suggesting Ink (uncredited)
D'Arcy Corrigan
as Villager (uncredited)
Jack Deery
as Officer in Charge of Barn Capture (uncredited)
Dwight Frye
as Reporter (uncredited)
Mary Gordon
as Screaming Woman (uncredited)
Bobby Hale
as Townsman at Pub (uncredited)
Stuart Hall
as Constable (uncredited)
Tiny Jones
Violet Kemble Cooper
as Woman (uncredited)
Crauford Kent
as Doctor (uncredited)
Paul Kruger
John Merivale
Monte Montague
as Cop (uncredited)
Jack Montgomery
Charles Morton
as Party Guest (uncredited)
Bob Reeves
as Detective Hogan (uncredited)
Jack Richardson
as Official (uncredited)
Tom Ricketts
as Old Farmer with Barn (uncredited)
Kathryn Sheldon
as Orphanage Worker (uncredited)
Emma Tansey
as Old Woman Listening to Radio (uncredited)
Jameson Thomas
as Hospital Doctor (uncredited)
Leo White
as 2nd Man Calling Police ('Frost')(uncredited)
Bert Young
as Railroad Switchman (uncredited)
Heinz Roemheld
Original Music Composer
Ted J. Kent
Editor
R.C. Sherriff
Screenplay
Arthur Edeson
Director of Photography
James Whale
Director
H. G. Wells
Novel
Charles D. Hall
Art Direction
Carl Laemmle Jr.
Producer
Cleo E. Baker
Visual Effects
William Hedgcock
Sound Recordist
Gilbert Kurland
Sound Supervisor
John Kemp
William Schiller
Orchestrator
Joseph A. McDonough
Assistant Director
King D. Gray
Camera Operator
Music Supervisor
John J. Mescall
W. Franke Harling
Music
Maurice Pivar
Editorial Manager
Conductor
Visual Effects Camera
Roswell A. Hoffmann
Jack Eagan
Assistant Camera
Bill Heckler
Peter Abriss
Grip
Carl Laemmle
Presenter
Wally Kirkpatrick
Props
Roman Freulich
Still Photographer
Fred Stoll
Frank D. Williams
Visual Effects Supervisor
Jack Pierce
Makeup Artist
John P. Fulton
Special Effects